Cabezuela del Valle is a town with around 2,150 residents founded in the medieval period, originally belong to Sexmo de Plasencia. The town had an important Jewish community in the Middle Ages, before being forced to move in 1492 by decree of the Catholic monarchs. This sent the town into economic decline. It was further negatively impacted by several wars in the region.
The town saw a large number of its population tried before the Inquisition and subjected to auto-da-fe during the late 1400s. The vast majority were found guilty of being Jews with most of the town being accused as the town had a history of being a place where many followers of Moses lived.
Podemos Cabezuela del Valle promoted an October 2020 effort by Extremadura Entiende to print information signs to make lesbians, bisexual women and transwomen more visible and provide information to those women by giving them contact details for their organization.