The historic district of La Latina is almost entirely located in the barrio. It takes its name from a hospital opened in the area in 1449. It is largely served by Metro La Latina.
Calle del Espejo, 4, is the unassuming building where Romantic musician and poet Angela Grassi lived late in life. She died there on 17 September 1883.
Calle de Bailén is the street where Elena Fortún was born on 18 November 1886 with the name María de la Encarnación Gertrudis Jacoba to Leocadio Aragoneses Esteban and Manuela Urquijo Ribacova. The family lived there after her father moved to Madrid to get a position of halberdier of the Palace. Her parents met in Madrid, with her mother residing in Madrid after having been widowed in her first marriage.
Escuela del hogar y Profesional de la Mujer was a school designed to prepare young women for a life of fulfillment in the home as wives and mothers. The original location of the school when they were founded in 1911 was at Cuesta de Santo Domingo. A year later in March 1912, they moved to Paseo de la Castellana, 60 and a bit later, they moved down the street to Paseo de la Castellana, 72. In 1932, they moved to Calle Pinar, 7. Rosa Chacel was a member of the first class of the school, developing her feminist beliefs at the school. Matilde Calvo was a teacher there.
Victorina Durán lived in an attic apartment without an elevator on Calle del Reloj near Plaza de España when she returned to Spain in 1963.
Universidad Central, originally located at Calle de San Bernardo, 47, 49, was one of the forerunners to Universidad Complutense de Madrid. It was founded in 1842, and in 1857 was the only one in Spain authorized go give a degree with the title of Doctor, an honor it would hold until 1954. Among its students was Fernanda Monasterio Cobelo. Her doctoral thesis was directed by Gregorio Marañón, wth the title Depressive symptoms in acromegaly.
Catedral de la Almudena, located at Calle de Bailén, 10, is Catholic cathederal consecrated on 15 June 1993 in a ceremony conducted by Pope John Paul II. Toledo was the original capital of Spain, and the seat of the Roman Catholic church in Spain did not move with the country until the modern era, with construction for the cathedral only beginning in 1879 on the site of a mosque destroyed by Alfonso VI in 1083. The Civil War put a halt to construction, with the project abandoned until 1950 when construction started anew in a style designed to match the Palacio Real which sits opposite the site. In 2004, FELGTB convened a mass kissing to protest the Catholic Church’s intolerance of homosexuality and Partido Popular’s support of that intolerance. Around 300 gay and lesbian people attended the event.